The Cheetah Trial

CHEETAH – Cluster randomised trial of sterile glove and instrument change at the time of wound closure to reduce surgical site infection. A trial in low and middle income countries (LMICs)

CHEETAH is an international, multicentre, 2-arm, cluster randomised controlled trial with an internal pilot to evaluate the use of separate sterile gloves and instruments for wound closure to reduce SSI rates in patients undergoing surgery with an abdominal incision. Clusters are defined as hospitals.
CHEETAH is after FALCON the second global surgical trial from the NIHR-GSU network.

Aims & Objectives

  • Primary Objective

    The primary objective of the CHEETAH RCT is to assess whether the practice of using separate, sterile gloves and instruments to close wounds at the end of surgery can reduce surgical site infection at 30-days post-surgery for patients undergoing clean-contaminated, contaminated or dirty abdominal surgery, compared to current routine hospital practice.

  • Secondary Objective

    The secondary objective of the CHEETAH RCT is to assess the impact of changing gloves/instruments prior to wound closure compared to current routine hospital practice on secondary clinical outcomes up to 30 days post-surgery including: SSI during the in-hospital stay, re-admission, re-operation, length of hospital stay, return to normal activities, and death.

  • The recruitment target is a total of 12,800 participants from 64 clusters (hospital), each including up to 200 participants.

Collaborating countries

CHEETAH is an international trial being conducted in multiple NIHR funded countries. Click on the map below to see participating countries.

Trial summary

Surgical site infection (SSI) represents a major burden for patients, doctors and health systems around the world, but is potentially preventable. SSI is the most common postoperative complication across all income and development settings, and the most common healthcare